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, (C/C) T2255C VKORC1.

. , Watzka et al. VKORC1 GGCX - ͳ [93]. Marieke et al., , VKORC1, NQO1 GGCX ( rs6738645, rs699664, rs10179904, rs11676382, rs17026447, rs2028898) . H1 GGCX ' [55].

Vanakker et al. , G3730 VKORC1 8- Arg325Gln GGCX - . , GGCX VKORC1 [48].

Kimura et al. GGCX, VKORC1 CALU C- S- . Ƴ, (Arg325Gln GGCX), , [92].

' . / 2255 VKORC1, . 6,8 , 25 /2 5,3 , 糺 4,2 , , , 4,1 , T/T. , G3730A VKORC1, 4 , . , , , , .

Ҳ , ' . Ҳ VKORC1. Ҳ, ( A- G3730A VKORC1) - , .

Ƴ- (T/C+C/C) T2255C VKORC1 , (T/T), - -. , , , , Ҳ.

. Ҳ (G/A) G3730A 2 , - (T/C) T2255C 5,5 , .

, . , Bagger et al., VKORC1 VDR , , GA (VKORC1) , BsmI TaqI (VDR) [124]. Filus et al. ', ' FokI . (F/F, F/f) - , (f/f) [103].

, VKORC1 㳺.

.

' , , , , , , .

. : 70 - [7]. 35 70 30 %, 2-3 , [16]. , 8 % 52 % 40 70 [138].

, , Ҳ, . , / ( 2255 VKORC1), Ҳ 2,5 , T/T.

, - [16]. , , .

, 10 % - [66]. , , , , - , Ҳ [74]. , , , 22 % , . 64 % , [16].

, y C/C ( 2255 VKORC1) 25 /2 Ҳ 4 , (T/T).

Fox et al. 70987 SNP . , ' , VKORC1 [52].

³, 20/10 . . ( ), 115/75 . ., - [3]. , 1 15 12,7 [16].

, , a VKORC1 , . . : a VKORC1 Ҳ . , VKORC1.

. (G/A) G3730 VKORC1 Ҳ 糿 5 , .

1/3 [139]. , , 60 2 , , [30]. , , 4 , , [44]. ³ , 3 [54].




140 .


, . , Ҳ .

2- - 㳿, , , . - 2- (6575 % ) [36].

2- 24 , 6-10 , .

Ortlepp et al. BsmI (VDR) C1173T (VKORC1) 2- , . , BsmI VDR 2- [119].

50- . , , 8 , , . , , ' , , , [29]. 15 , , ' , ' . , 糿 [59].

Ҳ, . , , .

, a VKORC1 , . , , .

. ' T2255C G3730A 3UTR VKORC1 , .

1. (Ҳ) T2255C VKORC1. / Ҳ 2,2 , (T/T) ( = 0,013).



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Բ ղ̲ Ҳ PHYSICS AND CHEMISTRY OF SOLID STATE . 13, 1 (2012) . 73-76 V. 13, 1 (2012) P. 73-76 621.315.592. ISSN1729-4428 .. , .. , .. , .. , . , 57, -, 76000, , E-mail: fcss@pu.if.ua ,...

2 (72) 2013 636.085.532/631.363 .., .-. , .., .-. , .., ³ ֲ ò ̲ ֲ Ѳ ز ...

35:341.233.1+351.82 . . Ͳֲ Բ . - . A study of vectors modernization of public financial control. The necessity of improving the existing legal mechanisms of state financial control in Ukraine. ...

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005.2: 658 -Ͳ ϲ вҲ ί ò ϲȪ1 .., ..., , .., 㳿 , . : , , , , , . . .,...

URL: http://www.enemo.org.ua/ENEMO%20FINAL%20 STATEMENT%202006%20ukr.pdf. 8. . 2002 , 2002. URL: http://www.ucipr.kiev.ua/ ukrainian/adminresurs/001.html. 9. . 1999 -2004 // RU. 2003. 32 (327). URL: http: // www. polit. com.ua/?cgid=5&PHPSESSID=d1b71d947caaa03f2a29bcfa65015568&mpid=9®id=637&spoid=2& offs=70&poid=2&id=1866/. 10. ...

òͲ ˲ 616.33 002.44 089 06:616.61 002.3 036.12] 092.19 Ͳ̲ Dz Ͳ ϲ: ϲ ֲ ί C.. , .. : ﳺ, 18, , , , . ...

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ISSN 1813-6796 ² 2012 6 , 677.025 . . , . . ͲͲ Ҳ ’ Ͳ ' - , ...




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