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̲Ͳ ² ̲Ͳ Ͳ _ : ...

-- [ 8 ] --

1. Ƴ- (T/C+C/C) T2255C VKORC1 , (T/T), - -. , , , , Ҳ.

2. Ҳ (G/A) G3730A , - (T/C) T2255C VKORC1 5,5 , .

IJ 5

˲Բ VKORC1

ֲ ² Ͳ

̲

, . , , [14,70].

Ҳ , , , , .

. 5.1 Ҳ T2255C, G3730A VKORC1.

Ҳ G3730A VKORC1. T2255C, (C/C) (4,73 0,15 /) (8,37 0,34 ) (77,4 2,34 %), .

   

: F Գ; P ; n Ҳ . T2255C Ҳ (. 5.1).

Ҳ, C/C, , . T2255C Ҳ, , 2 ( 20), 25 /2 ( 21), 糺 ( 22), , ( 23), ( 24).

=0,009 % (+) (-)

   

. 5.1 VKORC1 T2255C Ҳ ( ) ( ). 2- ϳ T2255C Ҳ , , (. 5.2).

, , , 6,8 , T/T (P = 0,027).

A- , G-, , 25 /2 (P = 0,017), (P = 0,022) , (P = 0,026) (. 5.2).

   

: (T/T);

CR ; SE ; WS ;

P ; OR ; CI G3730A VKORC1, ' SNP . , , , , ( 25) ( 26). , ( ), (G/G), 4 , (G/A+AlC/Cla) (. 5.3).

' Ҳ, .

5.3 Ҳ ( ) G3730A VKORC1

   

: (G/A+AlC/Cla);

CR ; SE ; WS ; P ; OR ; CI (, , , ), ' SNP .

, VKORC1 Ҳ :

1. , , Ҳ (C/C) T2255C VKORC1.

2. C/C T2255C VKORC1, T/T i T/C . 6,8, 25 /2 5,3, 糺 4,2, ,

4,1 , T/T. , G3730A VKORC1, 4 , .

   

Ҳ VKOR1 2255 . , (/) Ҳ 2,2 , (/, /).

.

Porojan et al. ' VKOR1 KLOTHO . , 1173 VKOR1 [95].

Wang et al., 2255 VKORC1, , [132]. Hindorff et al., ' VKORC1, 2255C, , , SNP , [33].

2010 Shyu et al. ' GGCX (Gln325Arg), VKORC1 (G3730A) NQO1 (Pro187Ser) . c . , [53].

, - - , ' [18, 19, 105] .

, Crosier et al. [71] , T-138, G-7A Thr83Ala MGP () , .



140 .


SNP . . SNP , . , , MGP MGP , , , . , MGP MGP , , .

, ' ( , ). , 㳿.

, Bos et al. [27] ' , , . , ' , . , , -, , , .

, , VKORC1 .

䳿 , [32]. , - , . . 䳿 [123, 136], VKOR . , , [13, 99] . , , , - . 2255 G3730A, Ҳ. , , , . , a VKORC1 - 㳿.



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 >>  . C 01.02.00
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