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Nature 5 2004 2 , VKOR1 [60, 75]. Rost VKORC1 . , 4- Mb 16 2 FMFD 4 ' . , 5126 3 , 163-. , 1 (VKORC1). . , FMFD C292T , 98 . 26 - A416C ; 15 SNP. VKORC1 .

Li VKORC1 16p12-q21. 13 - , , . (), . , MGC11276 , 16p11.2, VKOR . VKORC1 (S. frugiperda) , VKORC1 . , VKOR . In vivo, , , , .

VKORC1 ﳺ, 16- (16p11.2) -. 163 . 5126 , 3 , .

117 - , 1. ' - : G-1639A (rs9923231), C1173T (rs9934438), 2255 (rs2359612) 3'-UTR G3730A (rs7294).

. 1.2 VKOR1

G-1639A -, CA/GNNTG [131]. Yuan et al. SNP , A- ' VKORC1 [10].

Wang et al. . HepG2- , -1639A- ' 2 -1639G-. HepG2- [102].

VKORC1 .

SNP VKORC1 Rieder et al. [37]. G6853C (rs17886369), VKOR 21-25 % . , G- . , (G/G ) 6,06,2 , (/G) 4,34,9 / 2,73,4 .

, : G-1639A (rs9923231) [133] C1173T (rs9934438) [8]. , , G- 1639- VKORC1, -.

, G-1639A 1173T ' VKORC1 .

5 SNP VKORC1, : T-4931C (rs719616114), G-1639A (rs9923231), C1173T (rs9934438), G1542C (rs8050894), C7566T (rs2359612), 2 .

' , ᒺ [102].

- , , VKORC1 - . , Teitchert et al.

, , - C1173T 1 VKORC1 , [126].

Wang et al. , - 2255- VKORC1 (2255T ) . , / / , T/T [132]. Lemmens et al., , 1173T [65].

Hindorff et al. ' T2255C, C698T G3730A VKORC1 , 볿. , SNP [33]. T2255C VKORC1 볺 Verstuyft et al. [130]. Smadja et al. VKORC1 볿, G-1639A [76]. Lacut et al. , / 1173T ' 볿 [128].

, ' VKORC1 - , SNP , , .

1.3 , , . , . ³ 10 , . , , , .

, . F2 , . , . 20210 G/ , , . - [104, 120]. 20210 G/ , [106].




140 .


F5 , V ( ). .

1691 G/A (R506Q) F5 , . 볿, [42, 43, 115, 117].

F7 , VII. VII, III, IX X, ' .

Thr353Gln (10976A) 1289 G/A . - [12, 91].

P2Y12 , P2Y, . 12 1/2 , 2 ' [77].

, . MMP1 , 1 (MMP1). MMP1 I, II III , , . MMP1 . 2G 1607 1G/2G MMP1 , . 2G2G [97].

MMP3 , MMP3, II, III, IV, IX X , , , , MMP ( 1, 7 9). 3 . MMP3 , , [109, 122].

MMP9 , MMP9. IV V . - SNP 1562 / ' [49].

MTHFR , . 5,10- 5. MTHFR 쳿, , . 677 C/T , [64, 83, 87].

NOS3 , NO-, . Kullo .



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