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- (GGCX). GGCX - [96].

- , , ' , [25, 50]. - [125] . , K ( (KH2)) 2,3- (KO), in vivo, KH2 . - , [108, 126]. , (KO), , : , KH2 . , KO , (VKOR).

³ (VKOR) , - K- (II, VII, IX, X,). VKOR 䳿 , , , ﳿ [15, 134, 137].

, , - , S, Z , : , Gla-, S, Gas6, , PRGP1, PRGP2, TmG3, TmG4. VKOR , , , , , [121].

VKOR 1970 [24], [28]. VKOR , - , [100]. , , [28].

VKOR Lee et al. [68]. , , 䳺 200S , VKOR . VKOR 2,5-3,0 y KH2, .

VKOR 200S . - (WSP) 14-17 200S , N-[3H]- ([3]NEM) . , KO, , , [3]NEM WSP. , [3H]NEM , ', VKOR . , , , .

, VKOR , VKOR (-) (-), KO. Cain et al. [26] Bio-Gel P-100-. , , , VKOR . , -S (GST) - - , ' KO . , , , , [111]. , .

, VKOR . , VKOR [60, 75], , 163- CXXC . T. Li . [60] VKOR, VKORC1 ( 1) [75], , , . VKOR 93% [100]; - VKOR .

, , , 2. , VKOR , , ' in vivo.




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³ (VKOR) ( 18235 ) 163 , 2,3- () (H2), , - - .

㳿 , VKOR , , [72, 129]. CXXC-, [39]. ( 132 135) ' ( 139) (. 1).

. 1.1 VKOR . - , , , , , [135]. VKOR , ' [107]. VKOR : (1) - (a C-terminal endoplasmic membrane retention signal (Lys-Lys-X-X or Lys-X-Lys-X-X )); (2) (a transmembrane domain) [47].

1.2 ' - VKORC1 (FMFD).

FMFD - ,

- II, VII, IX X. Fregin FMFD VKORC1, K . 16 [57]. 16p12-q21 .

Rw (war) 16 , , Rw war 16 .



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685.513.685 IDENTIFICATION OF THE PARAMETERS OF ELECTRO-MECHANICAL SYSTEM MODEL BASED ON GENETIC ALGORITHMS S. Baluta, L. Kopulova, J. Klymenko National University of Food Technologies Key words: ABSTRACT Two-mass mechanical model The article presents a method of identification based on genetic Electro mechanical systems algorithms, the mechanical parameters and their optimization Genetic algorithms for a two-mass electromechanical system. An algorithm for the...

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