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, N N.

, N 䳿. , N N, [26].

, , , 䳺, ., NO [70].

, NO- 1,9 ( 4.5). - 1,2 . , NO- . NO- - .

, NO- .

4.5. - ﳿ ³ .. [110] . : , , , , , , . , , .

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(, sIg A .); , ; , ; ; ; .

1 108-108 / ( 1014 /). Streptococcus spp., Neisseria spp., Veillonella spp., Staphyllococcus spp., Fusobacterium spp., Corynebacterium spp., Haemophilus spp., Lactobacillus spp. Bacteroides spp. Actinomyces spp. Candida spp. (Entamoeba gingivalis). ̳ , , , . ̳ . 4.7.

̳ , , , .

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(quorum sensing). , . - , . 㳿 - . 㳿 , , , .

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, [110].

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P. gingivalis, T. forsythia, T. denticola, A. actynomycetemcomitans, P. intermedia.

P. gingivalis - , - (Kgp) ' (Rgp) . ֳ , ' , , [249]. , P. gingivalis , () , [80, 211], , [24].

in vitro P. gingivalis (: S. sanquis, S.




140 .


cordonii, S. mitis, S. cristatus Actynomycesnaeslundii), (F. nucleatum, T. denticola, T. forsythia), P. gingivalis [269].

: T. forsythia , . 䳺 [269]. ' (BspA) [163]. T. forsythia , . , - P. gingivalis, - S. cristatus [24, 80].

T. denticola - , ' . T. denticola , . T. denticola , , , 䳿 . , ' . T. denticola [80].

A. actynomycetemcomitans - - - [24, 243]. - , ' , , , [24, 80]. , A. actynomycetemcomitans (), , , [80, 243].

. actynomycetemcomitans 糿 , - 糿 , [24].

P. intermedia - , , . , sIg A, Ig G, . P. intermedia , -1 ( ), -6 ( - -), -8 ( ) [24, 80].

4 䳿 : , , [80].



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