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4. S. globisporus 1912, . 30 28 . lndE, lndF, lndA, lndB, lndC, lndD, lndL, lndM, lndN, lndO, lndP, lndV, lndZ4, lndZ6, lndZ5 , lndG, lndH, lndQ, lndR, lndS, lndT, lndZ1, lndZ3 , lndGT2, lndGT1, lndGT4 , lndJ , lndI lnd-.

5. S. kanamyceticus, , (kanA, kanB, kanC, kanD kanG). S. kanamyceticus. kanB kanD , .

6. S. kanamyceticus 1 genR10 kmrB, 16S , , . ij , kmrB, 㳿 S. fradiae M. zionensis.

7. - S. kanamyceticus - 7715-8217 ... , kmrB Kan- - kan12 genR8 genR10, .

8. S. kanamyceticus S. globisporus E. coli. lnd- S. globisporus.

9. , RifR-, CmlR-, TsrR- StrR- Sacch. erythraea, CmlR- S. ambofaciens, DnrR DxrR S. peucetius subsp.caesius, GenR- S.

kanamyceticus . , rif-, str- tsr- Sacch.

erythraea.

10. , S. kanamyceticus S. peucetius subsp.caesius .

11. dnrI cpx S. peucetius subsp.caesius .

12. lndGT4 S. globisporus 1912 F H, G. .

˲ ֲ

1. .., .., .., .., ..

Streptomyces coelicolor A3(2) // .1989..25. 4..626-634.

2. .., .., .., .. - Streptomyces erythraeus // . . 1990. .35,12.-.11-13.

3. .., .., .. - Streptomyces erythraeus // . . 1990. .35,12.-.18-21.

4. .., .., .., .. Streptomyces coelicolor A3(2) // . . 1990. .35,12.-.21-23.

5. .., .., .., .., .. Streptomyces erythraeus // .-1992.-.21.-.39-45.

6. .., .., .., .., .. Saccharopolyspora erythraea // . . 1993. .38,1.-.24-28.

7. .., .., .., .., .., ..

Saccharopolyspora erythraea // . . 1993. .38,6.-.3-8.

8. .., .., .., .. Streptomyces kanamyceticus // . . 1995. .40,1.-.3-7.

9. .., .., .. Streptomyces kanamyceticus, 2- // . . 1996. .41,6.-.10-14.

10. .., .., .. Streptomyces kanamyceticus, // . . 1996.

.41,6.-.15-20.

11. .., .., .. , Streptomyces kanamyceticus // . . 1997. .42,4.-.8-12.

12. .., .., .. Saccharopolyspora erythraea, // . . 1997. .42,1.-.7-11.

13. .., .., .. Saccharopolyspora erythraea // . . 1997. .42,8.-.14-20.

14. .., .., .., . Streptomyces kanamyceticus // . . 1998. .43,4.-.14-19.

15. Demydchuk J., Oliynyk Z., Fedorenko V. Analysis of a kanamycin resistance gene (kmr) from Streptomyces kanamyceticus and a mutants with increased aminoglycoside resistance // J.Basic Microbiol. 1998. Vol.38, N4.- P.231-239.

16. .., .., .., .. Saccharopolyspora erythraea, // . .

1999. .44,3.-.5-10.

17. .. - Streptomyces // . kanamyceticus 1999..3.1-2..111-117.

18. ., ., ., ., ., . Streptomyces globisporus 1912, Streptomyces peucetius ATCC29050 Streptomyces peucetius subsp.caesius ATCC27952 // ³. .-...-2000.-.25.-.49-60.

19. .. Streptomyces ambofaciens // ³. .-...-2000.-.25.-.67-73.

20. ., ., ., . - Streptomyces globisporus // ³. .-...-2000.-.26.-.46-53.

21. ., ., . Streptomyces coelicolor A3(2) // ³. .-...-2000.-.26.-.63-67.

22. .., .., .., .., .., .., .., . - // . - . .-2000.-8.-.27-31.

23. .., .., .. Escherichia coli Streptomyces globisporus 1912 c pSET152 // .-2001.-.37,10.-.1340-1347.

24. Ostash B., Basiliya L., Gromyko O., Rebets Yu., Fedorenko V. Streptomyces globisporus 1912 mutants with altered landomycin biosynthesis // ³. . -. ..-2001.-.27.-C.106-112.




140 .


25. Pankevych K., Kruegel H., Fedorenko V. Cloning and sequencing of a putative positive transcription regulator gene of landomycin biosynthetic cluster of Streptomyces globisporus 1912 // ³. .

-. ..-2001.- .27.-.97-105.

26. Ostash B., Luzhetskyy A., Gromyko O., Fedorenko V. Transfer of plasmid from Escherichia coli to mutant strain Streptomyces globisporus LND900 with altered biosynthesis of antitumor antibiotic landomycin E // . . . -. ..2001.-10.-.147-149.

27. .., .. Streptomyces peucetius subsp.caesius ATCC27952, c // ̳...63,4.-.53-61.

28. .., .., .., .., .., .., .., .., .., .., .., .., .., .., .. // . 4 . / .: .. (. .) ..:,2001..1.-.469-476.

29. .., .., .., .., .., .., .., .. // . 4 . / .: .. (. .) . .:, 2001..1.-.462-468.

30. .., .. Streptomyces peucetius subsp.caesius c // ³.

ATCC27952-2, .-...-2002.-.28.-.105-113.

31. .., .. Streptomyces peucetius subsp.caesius ATCC27952-2 // -2002.-.18,2.-.91-95.

32. Luzhetskyy A., Fedoryshyn M., Hoffmeister D., Bechthold A., Fedorenko V. Gene cloning system for Streptomyces cyanogenus S136 // ³. .-...-2002.-.29.-.62-68.

33. .., .. Streptomyces peucetius subsp. caesius ATCC 27952-2 // . . 2002. .47,6.-.7-11.

34. C .., .., .., .., .., ...

Ŕ // ³.

. - . ճ, . 2002.-461.-.204-208.

35. Rebets Y., Ostash B., Luzhetskyy A., Hoffmeister D., Brana A., Salas J.A., Bechtold A., V.Fedorenko.

Production of landomycins in Streptomyces globisporus 1912 and S. cyanogenus S136 is regulated by genes encoding putative transcriptional activators // FEMS Microbiol. Let.-2003.-Vol. 222, Is.1. P.149

153.



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