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㳿, 1 2013 animals allowed to set the parameters of the norm of ...

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. When the IM was incomplete and MUC2 marking of MUC2, 25% goblet cells was positive, in 25% of patients with CAG with incomplete IM, the gastric mucin (MUC5AC) was (MUC5AC), observed as well, as for columnar epitheliocytes, it was characteristic that the gastric mucin (MUC5AC) has been (MUC5AC) 100% MUC2 found in 100% of patients observed, and as for MUC2, it (15 % ). was observed in small amounts (15 % of patients). IM has M, - ( I been recognized as either a complete or an incomplete II) ( III) [7, 8]. type IM, or as a small- (Type I and Type II) or large , (Type III) intestinal-type IM [7, 8]. Though these , , classifications have been generally accepted, they . overemphasize the characteristics common to cells in the , small intestine, while neglecting the existing gastric [6, 9], phenotype. But the results of our investigations coincide , with other researches [9, 10] that suggested dividing () (I intestinal metaplasia (IM) into two categories, i.e., a ). , mixed gastric and intestinal (GI) type, and a solely intestinal (I) type, based on the residual gastric phenotype J.R. Jass, M.I. Filipe, cells. Thus separation of gastrointestinal phenotype of IM ( unlike previous classification [8], which offered only ), intestinal types (mainly intestinal and colonic), will let us consider gastric and intestinal phenotype. It will let us , deepen our knowledge about the histogenesis of gastric . cancer and it confirms the heterogeneity of IM.

Conclusions

1. - 1. Mucin profile can be used for differential diagnosing - of types of metaplastic changes in gastric epithelium . and histological variants of gastric cancer.

2. - 2. MUC5AC expression of gastric mucins in columnar MUC5AC epithelial cells and goblet exocrinocytes marks the formation of gastrointestinal phenotype - incomplete 糿, intestinal metaplasia, along with the simultaneous MUC2. production of MUC2 by goblet cells.

3. 3. Mostly intestinal phenotype is characterized by MUC 5AC MUC 5AC absence in columnar epitheliocytes and MUC2 goblet exocrinocytes despite MUC2 production by 㳿, 1 2013 . goblet exocrinocytes.

4. MUC 6 糿, 4. MUC 6 may serve as a marker of pyloric metaplasia, its appearance in the cells of the glands shows pylorization and distribution of atrophic changes in . specialized glands of the stomach fundus.

5. 5. Decrease with the further ceasing of production of MUC 5AC protective MUC 5AC by columnar epithelial cells and , goblet exocrinocytes we have found us in areas of 糿 , severe dysplasia and IM adjacent to neoplastic altered , cells may serve as an additional criterion of early . malignancy of gastric mucosa.

˳

1. . . / . . , . . // . 2007. . 916.

2. . . () / . . // .- 1998.- 1.- .30-37.

3. .. / ..

, .. ,. .. ϳ // - .: , 2004.- 248 .

4. Allen A. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin / A. Allen, G. Flemstrom // Am. J. Pphysiol. Cell Physiol. 2005. Vol. 288. P. 143.

5. Cassaro M. Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype/ M. Cassaro, M. Rugge, C. Tieppo [et al.] // J. Clin Pathol. 2007. Vol. 60. P. 615-621.

6. Inada K. Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach / K. Inada, H. Nakanishi, Y. Fujimitsu [et al.] // Pathol. Int. 1997 - Vol. 47, 12. P.831-41.

7. Jass J.R. A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study / J.R. Jass, M.I. Filipe // Histopathology. 1979. Vol.3. P.191199.

8. Kawachi T. Studies of intestinal metaplasia in the gastric mucosa by detection of disaccharidases with Tes-Tape / T. Kawachi, K. Kogure, N.

Tanaka [et al.] // J. Natl. Cancer Inst. 1974. Vol. 53. P. 1930.

9. Niwa T. Mixed gastric- and intestinal-type metaplasia is formed by cells with dual intestinal and gastric differentiation / T. Niwa, Y. Ikehara, H.

Nakanishi [et al.] // J. Histochem. Cytochem. - 2005. Vol. 53, 1. - P. 75-85.

10. Rugge M. Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading / M. Rugge, P. Correa,. M. F. Dixon [et al.] // Alimentary Pharmacology & Therapeutics.- 2002.- Vol.- 16. -P. 1249 - 1259.

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MU 2, MU 5AC, MU 6 () x () .

, MUC5AC - , MUC 2.

MUC 5AC MUC2 . MUC 6 . , MUC 5AC , , .

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10.01.2013 . ..

   

- In mature white male rats submicroscopic investigation of the spleen has been conducted in the early stages after experimental burn . , 1 7 injury. There has been defined that adaptive-compensatory changes have been developed and signs of degradation are present in the structural - . components of the organ the first and seventh days after the burn.




140 .


: , , . Key words: spleen, submicroscopic changes, burn injury.

   



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