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㳿, 1 2013 animals allowed to set the parameters of the norm of ...

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㳿, 1 2013

animals allowed to set the parameters of the norm of

polarization properties of the thyroid and suprarenal

. glands tissues in rats.

. Prospects of further researches. Perspective in this direction is a study of polarization structuralness of glands . tissues at the conditions of the pathologic factors influence.

˳

1. . . / . . , . . , . . , [ .] // 2000. . 88, 3. . 495 498.

2. . . - / . . , . .

,. . // ... 2002. . 1, 1. . 69 74.

3. .. - ᒺ / .. : , 2000. 256 .

4. . . : : / .., . .

ϳ, .. [ i.] // : -, 2007. 314 .

5. .. / .. // . . 1997. .167. .517-539.

6. Yermolenko S. Laser polarimetry tomography of biotissue pathological changes / S. Yermolenko, O. Angelsky, A. Ushenko [et al.] // roc. SPIE. 2001. Vol. 4425. P. 117-123.

7. Ushenko A.G. Laser Polarimetry of Biological Tissue. Principles and Applications / A.G.Ushenko, V.P.Pishak. // in Coherent-Domain Optical Methods. Biomedical Diagnostics, Environmental and Material Science, ed. V.Tuchin. - Kluwer Academic Publishers, 2004. 67p.

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. .

: , , .

i 19.11.2012 . ..

   

The expression of mucin MUC 2, MUC 5AC, MUC 6 in MU 2, MU 5AC, MU 6 the gastric mucosa of patients with chronic atrophic gastritis with () complete and incomplete intestinal metaplasia (IM) and gastric 糺 () . cancer patients on the basis of gastrobiopsies material was , MUC5AC investigated. The expression of mucin MUC5AC in the columnar epithelial cells and goblet exocrinocytes as a marker formation , gastrointestinal phenotype - incomplete KM, along with the MUC2. simultaneous production of goblet cells MUC2 was revealed.

MUC Preferably intestinal phenotype characterized by the absence of MUC 5AC 5AC in columnar epithelial cells and goblet exocrinocytes despite the MUC2 . MUC 6 production MUC2 in the goblet exocrinocytes. MUC 6 may serve as 糿. a marker of pyloric metaplasia. Decrease with further loss of MUC 5AC products of protective MUC 5AC in the columnar epithelial cells and goblet exocrinocytes in areas of severe dysplasia and IM adjacent to 糿 , , neoplastic altered cells may serve as an additional criterion for early . malignancy.

: , Key words: mucins, precancerous changes of the gastric . mucosa.

   

㳿, 1 2013 . molecule. MUC 3 and MUC 4 present in the same cells MU 3 MU 4 are regarded as the original form for secretory mucins. As for the gel-forming mucins of the digestive tract, they . include: MUC 2, MUC 5AC, MUC 4B, MUC 6. They are : MU 2, MU 5AC, MU 4B, MU 6. actively expressed with epithelial cells and represent a variable number of peptides rich in serine, threonine and , , proline, coupled with a large number of oligosaccharide , chains. According to the information available [2], the . [2] expression of membrane glycoproteins increases nearly tenfold in transformed cells, and carbohydrate chains are , becoming shorter. Such changes of mucin-producing cells . are considered to be a test for carcinogenesis. Mechanisms . dz that are responsible for orientation of protein molecules in the bilayer of cytomembrans, stabilization of the spatial ' , structure of proteins, transmembrane and intracellular transport of substances (including transfer of hydrolytic , , enzymes from the Golgi complex to lysosomes), and molecular mechanisms of intercellular recognition are (, associated with the specific structure of the carbohydrate ), determinants of glycoproteins. As we know, these . , mechanisms play an important role in the maturation and differentiation of cells, histogenesis and organ , morphogenesis, contact inhibition of cell proliferation, , , providing immune surveillance. That forms the basis of . the most important manifestations of malignant growth [3]. [3].

, Today it is proved that chronic atrophic gastritis () . (CAG) is one of the main elements of carcinogenesis.

̳ According to the recommendations of the International (2002) : Atrophy Group (2002) two main types of atrophy are [10]. distinguished: metaplastic and non-metaplasic [10]. Non , metaplasic atrophy is characterized by loss of glands, accompanied by fibrosis or fibromuscular proliferation in lamina propria of gastric mucosa, as for metaplastic (); atrophy - there is a replacement of gastric glands by ( metaplastic ones (including enteric), which can happen in ), the setting of other signs of atrophy.



140 .


Disturbance of the . synthesis and secrete releasing by glandular cells, its , chemical composition change under the influence of - exogenous and endogenous factors in CAG with intestinal 糺 (). metaplasia (IM) have not been studied well enough. Such transformations are one of the most important components of mucosal barrier may be significant in relation to morphogenetic and clinical differences of CAG with KM . in different groups of patients.

Purpose. To study the patterns of mucin expression in cells gastric mucosa in precancerous , conditions depending on the type, degree of maturity and . their level of differentiation. To substantiate the diagnostic and prognostic value and to investigate prospects of using mucins as immunohistochemical markers of specific types 糿. and varieties of intestinal metaplasia.



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See discussions, stats, and author profiles for this publication at: http://www.researchgate.net/publication/276864502 ֲ IJ ί Ҳ . (. . , , ί Ҳ). TECHNICAL REPORT APRIL 2007 DOI: 10.13140/RG.2.1.1544.0805 DOWNLOADS VIEWS 7 AUTHORS, INCLUDING: Andrey Kovalchuk Natalia Kovalchuk Uzhhorod National University Uzhhorod National University...

̲Ͳ ² ֲ Ͳ ò .. () 13 2013 . ò Ҳ Ͳ ֲ 6.051701 㳿 , 㳿 ...

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1 (56) : 2012 innovative technologies in agriculture is the key to highly efficient and profitable process of production. The development of the domestic crop is by bringing into circulation of agriculture of the new plants, equipments, technologies, economy of labor and energy cost, and its increase quality and competitive of products in the world market. 60:167.2 (477/9) ˲ ˲ Ҳ ò ...

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ISSN 2079-8334. 㳿. 2014. 1(43) 12. Olbe L. Effect of omeprazole on gastric acid secretion and plasma gastrin in man / L. Olbe, C. Cederberg, T. Lind [et al.] // Scand J.Gastroenterology, 1989. Vol.24 . 27-32. NOINFLUENCE OF MELANIN ON ACTIVITY OF NO-ERGIC SYSTEM IN THE SALIVARY GLANDS TISSUES AT THE HYPERGASTRINEMIA .., .., .....




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