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ISSN 2079-8334. 㳿. 2014. 1(43) 12. Olbe L. Effect of omeprazole on gastric acid secretion and plasma gastrin in man / L. Olbe, C. Cederberg, T. Lind [et al.] ...

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ISSN 2079-8334. 㳿. 2014. 1(43)

12. Olbe L. Effect of omeprazole on gastric acid secretion and plasma gastrin in man / L. Olbe, C. Cederberg, T. Lind [et al.] // Scand

J.Gastroenterology, - 1989. Vol.24 . 27-32.

NO- INFLUENCE OF MELANIN ON ACTIVITY OF NO-ERGIC

SYSTEM IN THE SALIVARY GLANDS TISSUES AT THE

HYPERGASTRINEMIA

.., .., .. Sukhomlyn A.A., Neporada K.S., Beregova T.V.

17 -. The experiment was performed on 17 white male rats.

Prolonged use of proton pump inhibitors developed . - hypergastrinemia. In the conditions of omeprazole-induced - - hypergastrinemia pathological changes occur in the tissues of - the salivary glands - an imbalance of regulatory systems and - reduced functional reserve tissues of the salivary glands.

. - Introduction of melanin normalizes activity of NO-ergic system NO- . in the tissues of the salivary glands.

: , , Key words: omeprazole, hypergastrinemia, melanin, , . salivary glands.

10.01.2014 . ..

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ISSN 2079-8334. 㳿. 2014. 1(43) . 30 -, 180,0-200,0 , : , , .

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䳺 (r=1,08 /2) [9]. ֳ , 95 %, [14]. - 糿 0,1-0,2 % [10].

370 (' 1 ) (): 120 NaCl, 30 KCl, 5 MgCl2, 1,5 AT, 1 , 1 NaN3 ( -), 20 Hepes-- (=7,4), 0,1 ( Ca2+,Mg2+- ) [11]. Ca2+- Ca2+. Ca2+,Mg2+-- 370 (' 1 ) (): 150 Kl, 0,05 CaCl2, 5 MgCl2, 5 , 1 NaN3, 1 ( Na+, K+--), 20 Hepes-- (=7,4).

- ; 50-100/. [13]. 5 . 1 - : 1,5 , 3,7 % , 14 % , 5 % .

, . Na+,K+- - Mg2+ (1 ). Ca2+,Mg2+-- - Ca2+- . Ca2+,Mg2+-- :




140 .


(Ca2+,Mg2+-- - ) (Ca2+,Mg2+-- SERCA) Ca2+- Mg2+- Ca2+,Mg2+-- (0,1 ).

(, 2011), , (, 1986), 1- (, 2001).

, , [5].

ISSN 2079-8334. 㳿. 2014. 1(43)

Statistica for Windows

6.0 t ' . 0,05.

. K+, Na+, Ca2+, Cl- H+. , , . Na+ Ca2+ Na+,K+-- Ca2+,Mg2+--. Na+,K+-- , Ca2+-, Na+,K+-, Mg2+-- , K+ Na+ . Ca2+, Mg2+-- Ca2+ [6,8,15].

Na+,K+- 56,33,9 % 60,14,0 % (0,05) (. 1). Ca2+,Mg2+-- 56,32,8 % 66,94,2 % (0,05) (. 2).

Ca2+,Mg2+-. Ca2+,Mg2+-- . 65,64,5 %, 86,37,5 % (0,05) .

   

56,3

   



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